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    Time to peak plasma concentration is approximately one hour. Distribution � Although the plasma half life of spironolactone itself is short (1.3 hours) the half lives of the active metabolites are longer (ranging from 2.8 to 11.2 hours). Spironolactone is estimated to be 90% protein bound.
    No, Spironolactone is an aldosterone blocking agent blocking the effects of the adrenal hormone Aldosterone that is part of the renin angiotensin system, inducing water and salt retention, thus causing water overload and maybe high blood pressure

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