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Tramadol is well-established as a serotonin reuptake inhibitor.[41][42] In addition, a few studies have found that it also acts as a serotonin releasing agent (1–10 μM), similar in effect to fenfluramine.[68][69][70][71] The serotonin releasing effects of tramadol could be blocked by sufficiently high concentrations of the serotonin reuptake inhibitor 6-nitroquipazine, which is in accordance with other serotonin releasing agents like fenfluramine and MDMA.[68][70][71]
The maximum recommended dose is 400 mg per day, so if using it alone does not provide adequate relief, other medications can be used with Ultram (tramadol) to help manage the pain. For instance, if there is throbbing pain from tight muscles, a muscle relaxant, such as Flexeril (cyclobenzaprine) or Zanaflex (tizanidine) may be beneficial. NSAIDs (non steroidal anti-inflammatory drugs), such as Aleve (naproxen) or Motrin/Advil (ibuprofen) can be added to help reduce pain caused from swelling. If there is sharp shooting pain from the nerves, a medication, such as Neurontin (gabapentin) or Lyrica (pregabalin) may stop the nerves from firing. Your doctor will know the best pain management therapy for you specific situation and may also add physical therapy, chiropractic work, or other non-drug related therapy as well. Patti Brown, PharmD
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Tramadol is well-established as a serotonin reuptake inhibitor.[41][42] In addition, a few studies have found that it also acts as a serotonin releasing agent (1–10 μM), similar in effect to fenfluramine.[68][69][70][71] The serotonin releasing effects of tramadol could be blocked by sufficiently high concentrations of the serotonin reuptake inhibitor 6-nitroquipazine, which is in accordance with other serotonin releasing agents like fenfluramine and MDMA.[68][70][71]
The maximum recommended dose is 400 mg per day, so if using it alone does not provide adequate relief, other medications can be used with Ultram (tramadol) to help manage the pain. For instance, if there is throbbing pain from tight muscles, a muscle relaxant, such as Flexeril (cyclobenzaprine) or Zanaflex (tizanidine) may be beneficial. NSAIDs (non steroidal anti-inflammatory drugs), such as Aleve (naproxen) or Motrin/Advil (ibuprofen) can be added to help reduce pain caused from swelling. If there is sharp shooting pain from the nerves, a medication, such as Neurontin (gabapentin) or Lyrica (pregabalin) may stop the nerves from firing. Your doctor will know the best pain management therapy for you specific situation and may also add physical therapy, chiropractic work, or other non-drug related therapy as well. Patti Brown, PharmD
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