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    However, two more recent studies failed to find a releasing effect of tramadol at respective concentrations up to 10 and 30 μM.[72][71][64] In addition to serotonergic activity, tramadol is also a norepinephrine reuptake inhibitor.[41][42] It is not a norepinephrine releasing agent.[73][74][75][64] Tramadol does not inhibit the reuptake or induce the release of dopamine.[73][64]
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