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    Mechanism Of Action. ALDACTONE (spironolactone) is a specific pharmacologic antagonist of aldosterone, acting primarily through competitive binding of receptors at the aldosterone-dependent sodium-potassium exchange site in the distal convoluted renal tubule.
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    It is a steroid that blocks the effects of the hormones aldosterone and testosterone and has some effects similar to those of the hormone progesterone. Spironolactone belongs to a class of medications known as potassium-sparing diuretics. … It is available as a generic medication.
    Mechanism Of Action. ALDACTONE (spironolactone) is a specific pharmacologic antagonist of aldosterone, acting primarily through competitive binding of receptors at the aldosterone-dependent sodium-potassium exchange site in the distal convoluted renal tubule.

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